In Tokyo, the Nikkei 225 was 0.28 percent lower to 16,785.69 on Friday.
The Topix index closed at 1,616.62, while the Mothers market was higher, ending the session at 732.72 for a gain of 1.7 percent.
The pharmaceuticals sector was mixed.
Chugai Pharmaceutical (TYO: 4519) was 2.6 percent lower to ¥1,897 after it said it would need to extend clinical tests for a new anemia drug, while Daiichi Sankyo (TYO: 4568) gained 4.6 percent to ¥3,450 on the news that the US Food and Drug Administration approved its new blood pressure medication.
House builders were also mixed.
While Daiwa House Industry (TYO: 1925) dropped 0.1 percent to ¥1,499, Sekisui House (TYO: 1928; OTC: SKHSY) was 0.6 percent higher to ¥1,446.
In the real estate sector, Mitsubishi Estate (TYO: 8802) was down 3 percent to ¥3,290.
Consumer lender Takefuji (TYO: 8564) added 5.8 percent to ¥2,280 after it announced a share buy-back.
Camera and copier maker Canon (TYO: 7751; NYSE: CAJ) gained 2.6 percent to ¥6,270 on the possibility that it might also buy back shares.
Construction equipment manufacturer Mitsubishi Heavy Industries (TYO: 7011) was 1.9 percent higher to ¥751 on the announcement that it will supply a Chinese nuclear facility.